The Protein Kinase FactsbookProtein-Tyrosine Kinases (Factsbook)
- 418 Pages
- June 5, 1995
- 3.87 MB
- 9376 Downloads
Cellular biology, Molecular biology, Proteins, Life Sciences - Biology - Molecular Biology, Science, Life Sciences - Biochemistry, Life Sciences - Biology - General, Science / Molecular Bi
|Contributions||Grahame Hardie (Editor), Steven Hanks (Editor)|
|The Physical Object|
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The Protein Kinase FactsBook Protein-Serine Kinases serves as a handy reference for people working in the cell-signaling field so that basic information about a particular protein kinase can be retrieved rapidly with minimum searching in libraries and databases.
The list of protein kinases included in the book is restricted to those which. The Protein Kinase FactsBook: Protein - Tyrosine Kinases contains over entries on members of the family from vertebrates, Drosophila, higher plants, yeasts, nematodes, slime moulds and other organisms.
Entries provide information on: * Subunit structure and isoforms * Genetics * Sequence database accession numbers * Domain structures. Buy Protein Kinase Factsbook CD-ROM on FREE SHIPPING on qualified orders Protein Kinase Factsbook CD-ROM: Grahame Hardie: : Books Skip to. Protein kinase factsbook.
London ; San Diego: Academic Press, © (OCoLC) Online version: Protein kinase factsbook. London ; San Diego: Academic Press, © (OCoLC) Document Type: Book: All Authors / Contributors: The Protein Kinase Factsbook book G The Protein Kinase Factsbook book Steven Hanks.
Purchase The Protein Kinase Factsbook, Two-Volume Set - 1st Edition. Print Book & E-Book. ISBNTaken together they compile everything you wanted to know about proteins but were too busy to look for.
The Protein Kinase FactsBook: Protein - Tyrosine Kinases contains over 65 entries on members of the family from vertebrates, Drosophila, slime moulds and other organisms.
SRC protein kinase activity is enhanced in some human colon cancers, skin tumors, The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS.
The protein kinase factsbook. Publication date Topics Protein kinases -- Handbooks, I.
Details The Protein Kinase Factsbook FB2
Protein-serine kinases -- II. Protein-tyrosine kinases Access-restricted-item true Addeddate Borrow this book to access EPUB and PDF files. IN COLLECTIONS. Books to : The Complement FactsBook, Second Edition, provides in-depth insights and an overview of the components of the complement new edition highlights the use of newly recommended complement nomenclature, covering new pathways and proteins and.
A protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).Phosphorylation usually results in a functional change of the target protein by changing enzyme activity, cellular location, or association with other human genome contains about protein kinase genes and they constitute about 2% of all human genes.
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription, and cell migration Family members - Isoforms.
Akt1 is involved HGNC: Proteins are the work horses of the cell. As regulators of protein function, protein kinases are involved in the control of cellular functions via intricate signalling pathways, allowing for fine tuning of physiological functions.
This book is a collaborative effort, with contribution from experts in their respective fields, reflecting the spirit of collaboration - across disciplines and.
Access Free Protein Kinase Facts Book ScienceDirect protein kinase facts book can be taken as with ease as picked to act. The Open Library has more than one million free e-books available.
Protein Kinase Facts Book - The Protein Kinase FactsBook: Protein - Page 6/ Protein kinases are one of the largest and most influential of gene families: constituting some 2% of the proteome, they regulate almost all biochemical pathways and may phosphorylate up to 30% of the proteome.
Bioinformatics and comparative genomics were used to determine the C. elegans kinome and put it in evolutionary and functional context. Kinases are deeply conserved in evolution, Cited by: The Eukaryotic Protein Kinase Superfamily.
In book: The Protein Kinase FactsBook, pp consulting The Protein Kinase Factsbook (42). and aPK HMMs, and Blast/psi-Blast with divergent kinase sequences, to identify protein kinase sequences inC.
elegans genomic and expressed sequences (Manning et al., ; Plowman et al., ). We identified protein kinase genes, including 20 atypical kinases, and an additional 25 kinase fragments or pseudogenes. All sequences. As key components of many cell signaling pathways, protein kinases are implicated in a broad variety of diseases, including cancers and neurodegenerative conditions, and offer considerable potential as tractable targets for therapeutic intervention.
In Protein Kinase Protocols, a panel of highly skilled laboratory investigators describe both basic and more sophisticated methods for the.
The protein kinase domain is a structurally conserved protein domain containing the catalytic function of protein kinases. Protein kinases are a group of enzymes that move a phosphate group onto proteins, in a process called phosphorylation.
This functions as an on/off switch for many cellular processes, including metabolism, transcription, cell cycle progression, cytoskeletal rearrangement InterPro: IPR Книга The Oncogene and Tumour Suppressor Gene Factsbook The Oncogene and Tumour Suppressor Gene FactsbookКниги English литература Автор: Robin Hesketh Год издания: Формат: pdf Издат.:Academic Press Страниц: Размер: 25,5 ISBN: Язык: Английский0 (голосов: 0) Оценка:Review"Within minutes of.
Protein and lipid kinases represent an important target class for treating human disorders. This review focus on 'the 10 things you should know about protein kinases and their inhibitors', including a short introduction on the history of protein kinases and their inhibitors and ending with a Cited by: Most protein kinases share a common ePK (eukaryotic protein kinase) catalytic domain, and can be identified by sequence similarity with Blast or profile hidden Markov models (HMMs).
The remaining atypical protein kinases (aPK) belong to several families, some of which have structural, but not sequence similarity to ePKs.
Protein Kinase A (PKA) is a protein that is dependent on cyclic AMP and without it, is is involved in signal-transduction pathways and phosphorylates proteins by adding a phosphate molecule consists of two subunits, a regulatory subunit and a calalytic subunits are inactive when cAMP is not bound.
When cAMP binds to a regulatory subunit a conformational. the protein kinase complements (‘kinomes’) of budding yeast,worm and fly, with known human classify kinases into putative orthologous groups with conserved functions and discuss kinase families and pathways that are unique,expanded.
The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains Article Literature Review (PDF Available) in Science () August with 4, Reads.
The main dendrogram (above right) shows the sequence similarity between protein kinase domains, derived from public sequences and gene prediction methods detailed in Manning et al. (Science,). Domains were defined by hidden Markov model profile analysis and multiple sequence alignment.
The initial branching pattern was built from. Yet remarkably, most of the kinase drugs in the clinic appear to target less than 20% of the known protein kinases. Consequently, the therapeutic potential of the broad majority of protein kinases remains to be investigated. The growing arsenal of protein kinases inhibitors will clearly have a profound impact on the treatment of human diseases.
This review gives a basic introduction to the biology of protein kinase C, one of the first calcium-dependent kinases to be discovered. We review the structure and function of protein kinase C, along with some of the substrates of individual by: Protein kinase A often acts at very discrete domains within cells.
Such spatial targeting results from interaction of type I regulatory subunits with proteins called A kinase anchoring proteins (AKAPs).A large number of distinct AKAPs have been identified and shown to colocalize protein kinase A to some of its specific substrates, including ion channels, cytoskeletal elements and centrosomes.
It gets added by a protein kinase. So protein kinase uses ATP, transfers that gamma phosphate to a protein. So now you have many proteins, more than half the proteins in our bodies exist either as a dephosphorylated molecule or as a phosphorylated molecule.
Complete with full-color presentations, Targeting Protein Kinases for Cancer Therapy defines the structural features of protein kinases and examines their cellular functions.
Combining kinase biology with chemistry and pharmacology applications, this book enlists emerging data to drive the discovery of new cancer-fighting drugs.
Download The Protein Kinase Factsbook EPUB
Janecek, M. et al. Allosteric modulation of AURKA kinase activity by a small-molecule inhibitor of its protein–protein interaction with TPX2. Sci.
Description The Protein Kinase Factsbook FB2
Rep. 6, ().Cited by: Protein Kinase A (PKA) Protein kinase A is an enzyme that covalently attaches phosphate groups to proteins.
It is also known as the cyclic AMP-dependent protein kinase. An extremely significant characteristic of protein kinase A is its ability to be regulated by the fluctuation of. The FactsBook Series has established itself as the best source of easily accessible and accurate facts about protein groups.
They use an easy-to-follow format and are researched and compiled by experts in the field. This Factsbook is devoted to nuclear receptors. The first section presents an introduction and describes the mode of action of the receptors in : Elsevier Science.
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